Vein Disease

Dr. Yan Katsnelson, MD

Medically reviewed byDr. Yan Katsnelson, M.D.Founder & CEO, USA Vein Clinics | Cardiac Surgeon | Harvard Medical SchoolReviewed July 2026
Vein disease is a condition in which the valves inside your leg veins stop working properly, allowing blood to pool instead of flowing back to your heart. As a result, blood pools in the lower legs instead of flowing efficiently back to the heart, increasing pressure within the veins and causing symptoms such as leg swelling, aching, heaviness, fatigue, and visible varicose veins.

Chronic venous insufficiency is a progressive condition, meaning symptoms typically worsen over time without treatment and may eventually lead to skin changes or leg ulcers. Fortunately, minimally invasive vein treatments can restore healthy blood flow, relieve symptoms, and help prevent the condition from progressing. If you’re experiencing persistent leg pain, swelling, or visible veins, a vein specialist can evaluate your circulation and recommend the most appropriate treatment.

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Common Vein Disease Conditions

Vein disease can lead to several related conditions, ranging from visible vein problems to more serious circulation disorders. While chronic venous insufficiency (CVI) is the underlying cause of many common vein conditions, others affect the veins in different ways and may require specialized evaluation and treatment.

Common conditions associated with vein disease include:

  • Chronic venous insufficiency (CVI): The most common form of vein disease, caused by damaged vein valves that allow blood to pool in the legs.
  • Varicose veins: Enlarged, twisted veins that develop when increased pressure stretches weakened vein walls.
  • Spider veins: Small, visible veins that may be cosmetic but can sometimes indicate underlying venous insufficiency.
  • Venous ulcers: Slow-healing wounds that can develop as a complication of advanced vein disease and poor circulation.
  • Deep vein thrombosis (DVT): A blood clot in a deep vein that requires immediate medical attention because of the risk of pulmonary embolism.
  • Superficial thrombophlebitis: Inflammation and clotting in a vein near the skin’s surface that should be evaluated by a healthcare provider.
  • May-Thurner syndrome: A condition in which compression of the left iliac vein affects blood flow and increases the risk of DVT.

Understanding the differences between these conditions can help you recognize symptoms early and seek the right care. A vein specialist can determine whether your symptoms are caused by chronic vein disease or another venous condition and recommend the most appropriate treatment.

Symptoms of Vein Disease

The symptoms of venous disease can cause both visible vein changes and uncomfortable symptoms in the legs. Some people notice spider veins or varicose veins first, while others experience swelling, aching, skin changes, or leg fatigue.

Common vein disease symptoms include:

  • Swelling in the legs, ankles, and feet
  • Tired, aching legs
  • Burning in the calf or thigh
  • Leg pain that improves with walking or elevation
  • Itchy, dry skin
  • Numbness or tingling sensations
  • Difficulty standing for prolonged periods
  • Open, non-healing leg wounds 
  • Varicose veins and spider veins

If you have visible veins or other signs of venous disease, consult a vein specialist for a diagnosis to alleviate symptoms and prevent disease progression.

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Symptoms of Venous Disease Requiring Immediate Attention

Some symptoms of venous disease may actually indicate a blood clot and warrant immediate medical attention. Seek medical attention immediately if you have:

  • Unexplained leg cramping 
  • Swelling in one leg
  • Skin that appears red and warm to the touch

What Causes Vein Disease

Vein disease develops when vein valves become strained over time. Repeated pressure weakens the valves, allowing blood to flow backward (referred to as reflux) and pool in the lower legs. This pooling increases internal pressure, which stretches the veins and eventually leads to visible varicose veins and other complications.

The legs are most affected by vein disease because gravity makes it more difficult for blood to return to the heart. This process places greater pressure on leg veins than on veins elsewhere in the body, especially when sitting or standing for prolonged periods.

Vein Disease Risk Factors

Many factors can lead to the development of vein disease. Some of these may be managed with lifestyle changes, although the best way to treat venous disease is through treatment from a vein specialist. 

Common risk factors for vein disease include:

  • Genetics: If one or both of your parents have varicose veins, you are considered at increased risk. 
  • Age: As you grow older, veins tend to weaken and become more susceptible to venous issues. Vein disease is more common in adults over age 50, but anyone at any age can be affected.
  • Sex and Hormones: Women are more likely to develop varicose veins due to hormonal influences and pregnancy-related changes.
  • Body Mass Index (BMI): Being obese or overweight increases pressure on your veins, causing them to enlarge. Maintaining a healthy BMI can lower your risk of developing venous insufficiency. 
  • Smoking: Smoking can weaken veins, impact blood circulation, and affect your overall health. 
  • Underlying health conditions: Some health conditions, including high blood pressure and diabetes, may increase your risk of developing vein disease. The best way to treat venous disease is to consult your doctor about any underlying issues.
  • Long periods of standing or sitting: Standing or sitting for prolonged periods affects circulation and can lead to vein disease. Most people benefit from getting at least 30 minutes of physical activity per day, five days a week, so take frequent breaks to move around and switch positions.

If you are at risk of developing vein disease, visit a vein specialist at USA Vein Clinics for personalized recommendations tailored to your level of risk and condition.

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How Is Vein Disease Diagnosed

Diagnosis begins with a consultation and physical examination. A vein specialist will review your symptoms and medical history and examine your legs for swelling, discoloration, or ulcers. Most patients also undergo a duplex ultrasound to evaluate blood flow, identify valve dysfunction, detect blood clots, and determine the severity of venous disease. An accurate diagnosis helps your vein specialist recommend the most effective treatment.

How to Treat Venous Disease

At USA Vein Clinics, we offer a range of minimally invasive, office-based vein treatments. These minimally invasive treatments effectively relieve symptoms of venous disease while lowering the risk of complications.

Our vein disease treatment options include:

  • Endovenous Laser Therapy (EVLT): With ultrasound guidance, a specialist inserts a very thin laser fiber into the diseased vein, then applies laser energy to seal it off.
  • Visual sclerotherapy: This technique can be used on very small veins, such as spider veins. Your vein specialist inserts a tiny needle with a sclerosant (a type of irritant) into the affected vein, causing it to collapse.
  • Varithena™ Vein Treatment: This treatment uses a type of medical foam to close off malfunctioning veins. When performing the procedure, your doctor will use ultrasound imaging for guidance.  
  • ClariVein®: ClariVein® uses a rotating catheter to inject a medical solution that closes targeted veins. 
  • Ultrasound-Guided Sclerotherapy: This treatment is for veins near the skin’s surface. Using ultrasound guidance, your vein specialist injects sclerosants that irritate and collapse targeted veins.
  • VenaSeal™ Treatment: This option uses a medical adhesive to seal varicose veins closed. Unlike other treatments, patients are not required to wear compression socks during recovery.

Your vein specialist will help determine which method is best for you. To get started, schedule an appointment online or call 888.768.3467 today.

Request a Consultation with USA Vein Clinics

USA Vein Clinics’ experienced vein specialists can help diagnose and treat venous disease. Our specialists provide non-surgical treatment for varicose veins, spider veins, and other vein disorders. We have state-of-the-art outpatient clinics located nationwide, making vein treatment accessible and convenient. 

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Vein Disease FAQs

What is vein disease?

Vein disease occurs when damaged vein valves allow blood to pool in the legs, causing aching, swelling, skin changes, varicose veins, and non-healing wounds. This pooling typically happens in the legs, feet, and ankles.  

Is vein disease deadly​?

Vein disease is not typically fatal, but complications can be serious. Advanced venous disease may cause ulcers, deep vein thrombosis (DVT), or even blood clots that can travel to the lungs and cause pulmonary embolism. If you notice symptoms of DVT, seek immediate medical care for a diagnosis and treatment to prevent serious complications.

What is chronic vein disease​?

Chronic vein disease refers to long-term valve dysfunction in the leg veins. When valves fail, blood pools in the lower extremities, causing swelling, pain, and visible changes in veins. 

Can vein disease be reversed​?

Vein disease cannot be reversed, but in some cases, symptoms can be managed through lifestyle changes, such as regular exercise and minimally invasive vein treatments. If you’re experiencing symptoms of venous disease, consult a vein specialist.

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